Estrogen effects on the hyperactivity induced
by (+)-MDMA and cocaine in female rats
by
Zhou W, Cunningham KA, Thomas ML.
Department of Pharmacology and Toxicology,
University of Texas Medical Branch,
Galveston 77555-1031, USA.
Behav Neurosci 2003 Feb;117(1):84-94

ABSTRACT

This study compared the effects of estrogen (E) on the hyperactivity induced by (+)-3,4-methylenedioxymethamphetamine (MDMA) with E effects on cocaine-evoked hyperactivity in female rats. Sprague-Dawley rats were ovariectomized (OVX); half of them received a 17beta-estradiol (E2) implant (OVX + E). Three weeks later, rats received saline, (+)-MDMA (1, 2, or 4 mg/kg) or cocaine (5, 10, or 20 mg/kg), and locomotor activity was monitored. OVX + E rats exhibited greater locomotor hyperactivity in response to both psychostimulants than did OVX rats. The enhanced response to cocaine appeared within 5 min following drug injection whereas the enhanced response to (+)-MDMA was delayed for approximately 30 min. The differential effects of E on hyperactivity may be due to the unique profiles of DA and 5-HT in response to (+)-MDMA and cocaine.

Men
MDMA
PMMA
History
Sexstasy
Controversies
Prenatal ecstasy
Alexander Shulgin
Prozac and ecstasy
Protect and survive
Human pharmacology
L-deprenyl and ecstasy
Women/ low midweek mood

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family