Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats
by
Cornish JL, Shahnawaz Z, Thompson MR,
Wong S, Morley KC, Hunt GE, McGregor IS.
School of Psychology,
University of Sydney,
A19 NSW 2006, Australia
Eur J Pharmacol. 2003 Dec 15;482(1-3):339-41

ABSTRACT

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30 degrees C) relative to normal laboratory temperature (21 degrees C). In the intravenous drug self-administration paradigm, hot temperature (30 degrees C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.

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