MDMA- and p-chlorophenylalanine-induced reduction
in 5-HT concentrations: effects on serotonin transporter densities
by
Boot BP, Mechan AO, McCann UD, Ricaurte GA.
Department of Neurology,
Johns Hopkins University School of Medicine,
Johns Hopkins Bayview Medical Center,
21224, Baltimore, MD, USA.
Eur J Pharmacol 2002 Oct 25;453(2-3):239-44

ABSTRACT

Tow levels of serotonin may reduce the density of the serotonin transporter (SERT) by either increasing trafficking or reducing synthesis; a "neuroadaptive response". To determine whether 3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in SERT density could be related to such a mechanism, p-chlorophenylalanine or MDMA was administered to rats, and brain serotonin and SERT density were measured. As expected, both treatments led to serotonin depletion 1, 7 and 14 days later. However, only MDMA reduced SERT density. This observation suggests that MDMA-induced reductions in SERT density do not represent neuroadaptive responses to decreased levels of brain serotonin, but may occur in response to some other stimulus or to the neurotoxic effects of MDMA.

History
Serotonin
MDMA/MDE
Controversies
Protect and survive
Serotonin-releasers
The serotonin syndrome
Ecstasy and serotonin synthesis
Ecstasy: long-term cognitive deficits?
Post-E serotonergic axonal resprouting
MDMA/Ecstasy and brain serotonin transporters

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family