Methcathinone (MCAT) and 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (MDMCAT) inhibit [3H]serotonin uptake into human platelets
by
Nicholas V. Cozzi, Alexander T. Shulgin, and Arnold E. Ruoho
Amer. Chem. Soc. Div. Med. Chem. Abs., 1998; 215: 152

ABSTRACT

The benzylic ketone analogs of the psychoactive phenylisopropylamine methamphetamine (MA), MCAT, and of 3,4-methylenedioxymethamphetamine (MDMA), MDMCAT, were synthesized and compared to the nonketo compounds for their abilities to inhibit reuptake transporter-mediated [3H]serotonin accumulation into human platelets. MCAT inhibited [3H]serotonin uptake into platelets with an IC50 of 33.7 ± 9.0 mM while MA exhibited an IC50 of 11.7 ± 1.0 mM; this difference was not significant. The methylenedioxy-substituted compounds were about 6-fold more potent (p < 0.05) than the unsubstituted compounds in this assay; MDMCAT displayed an IC50 of 5.8 ± 0.7 mM and MDMA had an IC50 of 2.1 ± 0.3 mM. The difference in potency between MDMCAT and MDMA was significant at p < 0.01. These results indicate that beta-keto derivatization of psychoactive phenylalkylamines does not have a major impact on the drugs' ablility to inhibit serotonin uptake and that phenyl ring substitutions can enhance potency.

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