Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine
by
Kuypers KP, Ramaekers JG.
Experimental Psychopharmacology Unit,
Department of Neurocognition,
Faculty of Psychology,
Maastricht University, Maastricht,
the Netherlands.
k.kuypers@psychology.unimaas.nl
J Psychopharmacol. 2005 Nov;19(6):633-9.
ABSTRACTA range of studies has indicated that users of 3.4-Methylene-dioxymethamphetamine (MDMA, 'Ecstasy') display cognitive deficits, particularly memory impairment, as compared to non-drug using controls. Yet it is difficult to determine whether these deficits are caused by MDMA or some other confounding factor, such as polydrug use. The present study was designed to establish the direct relation between MDMA and memory impairment under placebo-controlled conditions. Eighteen recreational MDMA users participated in a double blind, placebo controlled, 3-way crossover design. They were treated with placebo, MDMA 75mg and methylphenidate 20mg. Memory tests were conducted between 1.5-2h (intoxication phase) and between 25.5-26h (withdrawal phase) post dosing. Results showed that a single dose of MDMA caused impairment of immediate and delayed recall on a verbal learning task during the intoxication phase. However, there was no residual memory impairment during the withdrawal phase. Subjects reported more fatigue and less vigour, but no symptoms of depression during the withdrawal phase of MDMA treatment.Methylphenidate did not affect memory or mood at any time of testing. A single dose of MDMA produces transient memory impairment.Memory
Cognitive failure
Prenatal ecstasy
Spatial memory deficits?
Prospective memory deficits
Memory: Ecstasy v cannabis
Visuospatial memory deficits
Preprotachykinin A gene expression
Ecstasy, serotonin and verbal memory
Ecstasy and working memory task rules
and further reading
Refs
HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
