'Candyflipping': synergistic discriminative
effect of LSD and MDMA
by
Schechter MD
Department of Pharmacology,
Northeastern Ohio Universities College of Medicine,
Rootstown 44272-0095, USA.
mds@neou-com.edu
Eur J Pharmacol 1998 Jan 12; 341(2-3):131-4

ABSTRACT

TThe co-administration of D-lysergic acid diethylamide (LSD; 'Acid') and 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'; 'XTC'), has reached a prevalence that has allowed for the street terminology 'candyflipping' to describe the combination. Internet sites indicate a significant enhancement of central effects with their simultaneous use. In this preliminary observation, male Fawn-Hooded rats were trained to discriminate 1.5 mg/kg MDMA and were, subsequently, tested with doses of MDMA (0.15 mg/kg) or LSD (0.04 mg/kg) that each produced a saline-like response. Co-administration of these doses of MDMA and LSD synergized to produce a maximal MDMA-like response. The possible mechanism for synergistic action upon central serotonergic neurons is discussed to explain the observed effect.

MDMA
PMMA
SSRIs
Sexstasy
Serotonin
Dopamine
Fluoxetine
Entactogens
Empathogens
Fenfluramine
Serotonin dip
MDMA and MAO
Alexander Shulgin
Fluoxetine and ecstasy
L-deprenyl and ecstasy
Ecstasy and serotonin synthesis
Hofmann's LSD: My Problem Child

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