Synthesis and pharmacological activity of befuraline (N-benzo[b]furan-2-ylcarbonyl-N'-benzylpiperazine), a new antidepressant compound
by
Younes-El-Hage S, Labssita Y, Baziard-Mouysset G,
Payard M, Caignard DH, Rubat C.
Chimie Pharmaceutique, Faculte de Pharmacie,
35 Chemin des Maraichers, F-31400 Toulouse
Ann Pharm Fr. 2000 Jul;58(4):254-9.


ABSTRACT

The synthesis of 44 original amide derivatives of benzylpiperazine and some analogues of befuraline and piberaline is reported. All compounds have been tested as antidepressive agents. According to the tests, amides 1, 24 and mainly 31 (dihydrobefuraline) seem to provide elevated antidepressive activity.

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